Successful regeneration of large segmental bone defects remains a major challenge in
clinical orthopedics, thus it is of important significance to fabricate a suitable alternative …

The bone matrix plays an indispensable role in the human body, and its unique
biomechanical and mechanobiological properties have received much attention. The bone …

Collagen mineralization is a biological process in many skeletal elements in the animal
kingdom. Examples of these collagen‐based skeletons are the siliceous spicules of glass …

The host immune response to bone biomaterials is vital in determining scaffold fates and
bone regeneration outcomes. The nanometer-scale interface of biomaterials, which …

Biomineralization is the process by which organisms form mineralized tissues with
hierarchical structures and excellent properties, including the bones and teeth in …

Bone, as a mineralized composite of inorganic (mostly carbonated hydroxyapatite) and
organic (mainly type I collagen) phases, possesses a unique combination of remarkable …

The mineralized collagen fibril is the basic building block of bone, and is commonly pictured
as a parallel array of ultrathin carbonated hydroxyapatite (HAp) platelets distributed …

Biomineralization is an important tactic by which biological organisms produce hierarchically
structured minerals with marvellous functions. Biomineralization studies typically focus on …

In tissue engineering, bioactive materials play an important role, providing structural support,
cell regulation and establishing a suitable microenvironment to promote tissue regeneration …

The involvement of collagen in bone biomineralization is commonly admitted, yet its role
remains unclear. Here we show that type I collagen in vitro can initiate and orientate the …