Arrhythmias are common and contribute substantially to cardiovascular morbidity and
mortality. The underlying pathophysiology of arrhythmias is complex and remains …

The translation of novel discoveries from basic research to clinical application is a long,
often inefficient, and thus costly process. Accordingly, the process of drug development …

Transgenic animals are extensively used to study in vivo gene function as well as to model
human diseases. The technology for producing transgenic animals exists for a variety of …

Transgenic animal bioreactors represent a powerful tool to address the growing need for
therapeutic recombinant proteins. The ability of transgenic animals to produce complex …

Recent developments in studies of sperm‐mediated gene transfer (SMGT) now provide solid
ground for the notion that sperm cells can act as vectors for exogenous genetic sequences …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

Transgenic animals have become a key tool in functional genomics to generate models for
human diseases and validate new drugs. Transgenesis includes the addition of foreign …

Microinjection of foreign DNA into pronuclei of a fertilized oocyte has predominantly been
used for the generation of transgenic livestock. This technology works reliably, but is …

Background: RNA interference (RNAi) is a newly discovered cellular defense system that is
known to suppress replication of genomic parasites in model organisms. It has been widely …

The first transgenic livestock species were reported in 1985. Since then microinjection of
foreign DNA into pronuclei of zygotes has been the method of choice. It is now being …