Although genetic susceptibility explains the clustering of multiple sclerosis (MS) cases within
families and the sharp decline in risk with increasing genetic distance, it cannot fully explain …

Mitoxantrone, a synthetic anthracenedione, was developed in the 1980s as a doxorubicin
analogue in a program to find a cytotoxic agent with decreased cardiotoxicity compared with …

ContextEpidemiological studies suggest an association between infection with Epstein-Barr
virus (EBV) and risk of multiple sclerosis (MS). ObjectiveTo determine whether elevation in …

Background: Acute disseminated encephalomyelitis (ADEM) is a central nervous system
demyelinating disease that usually follows an apparently benign infection in otherwise …

Homing behavior and function of autoimmune CD4+ T cells in vivo was analyzed before and
during EAE, using MBP-specific T cells retrovirally engineered to express the gene of green …

We examined the effect of glatiramer acetate, a random copolymer of alanine, lysine,
glutamic acid, and tyrosine, on antigen-specific T-cell responses in patients with multiple …

Viral infections are though to play an important role in the pathogenesis of multiple sclerosis
(MS) potentially through molecular mimicry. An identical sequence was found in both myelin …

Lymphocyte recruitment into the brain is a critical event in the pathogenesis of multiple
sclerosis and experimental autoimmune encephalomyelitis. We developed a novel intravital …

Autoreactive T cells of CD4 and CD8 subsets recognizing myelin basic protein (MBP), a
candidate myelin autoantigen, are thought to contribute to and play distinct roles in the …

Hematopoietic stem cells (HSCs) are the earliest cells of the immune system, giving rise to B
and T lymphocytes, monocytes, tissue macrophages, and dendritic cells. In animal models …