[HTML][HTML] SWI/SNF complexes in hematological malignancies: biological implications and therapeutic opportunities
A Andrades, P Peinado, JC Alvarez-Perez… - Molecular cancer, 2023 - Springer
Hematological malignancies are a highly heterogeneous group of diseases with varied
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …
molecular and phenotypical characteristics. SWI/SNF (SWItch/Sucrose Non-Fermentable) …
Transcription factor networks link B-lymphocyte development and malignant transformation in leukemia
M Sigvardsson - Genes & Development, 2023 - genesdev.cshlp.org
Rapid advances in genomics have opened unprecedented possibilities to explore the
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …
mutational landscapes in malignant diseases, such as B-cell acute lymphoblastic leukemia …
[HTML][HTML] Defining the condensate landscape of fusion oncoproteins
Fusion oncoproteins (FOs) arise from chromosomal translocations in~ 17% of cancers and
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
are often oncogenic drivers. Although some FOs can promote oncogenesis by undergoing …
[HTML][HTML] Ultraviolet radiation shapes dendritic cell leukaemia transformation in the skin
Tumours most often arise from progression of precursor clones within a single anatomical
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to …
niche. In the bone marrow, clonal progenitors can undergo malignant transformation to …
[HTML][HTML] Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
Childhood B-cell acute lymphoblastic leukaemia (B-ALL) is characterised by recurrent
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
genetic abnormalities that drive risk-directed treatment strategies. Using current techniques …
[HTML][HTML] Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers
Abstract Analysis of mutational signatures can reveal underlying molecular mechanisms of
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
the processes that have imprinted the somatic mutations found in cancer genomes. Here, we …
[HTML][HTML] Hyperdiploidy: the longest known, most prevalent, and most enigmatic form of acute lymphoblastic leukemia in children
OA Haas, A Borkhardt - Leukemia, 2022 - nature.com
Hyperdiploidy is the largest genetic entity B-cell precursor acute lymphoblastic leukemia in
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …
children. The diagnostic hallmark of its two variants that will be discussed in detail herein is …
Somatic mutations of MLL4/COMPASS induce cytoplasmic localization providing molecular insight into cancer prognosis and treatment
Cancer genome sequencing consortiums have recently catalogued an abundance of
somatic mutations, across a wide range of human cancers, in the chromatin-modifying …
somatic mutations, across a wide range of human cancers, in the chromatin-modifying …
Advancing diagnostics and therapy to reach universal cure in childhood ALL
R Pieters, CG Mullighan, SP Hunger - Journal of Clinical Oncology, 2023 - ascopubs.org
Systemic combination chemotherapy and intrathecal chemotherapy markedly increased the
survival rate of children with ALL. In the past two decades, the use of minimal (measurable) …
survival rate of children with ALL. In the past two decades, the use of minimal (measurable) …
Genomic landscape of Down syndrome–associated acute lymphoblastic leukemia
Trisomy 21, the genetic cause of Down syndrome (DS), is the most common congenital
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …
chromosomal anomaly. It is associated with a 20-fold increased risk of acute lymphoblastic …