Per-and polyfluoroalkyl substances (PFAS) are ubiquitous drinking water contaminants of
concern due to mounting evidence implicating adverse health outcomes associated with …

ATP-binding cassette (ABC) transporters are involved in active pumping of many diverse
substrates through the cellular membrane. The transport mediated by these proteins …

The steroid hormones progestagens, estrogens, androgens, and glucocorticoids as well as
their precursor cholesterol are required for successful establishment and maintenance of …

The extensive metabolic demands of pregnancy require specific physiological and
anatomical changes. These changes affect almost all organ systems, including the …

Placentation is a reproductive adaptation that permits fetal growth and development within
the protected confines of the female reproductive tract. Through this important role, the …

Optimal development of the embryo and the fetus depends on placental passage of gases,
nutrients, hormones, and waste products. These molecules are transferred across the …

ABSTRACT Introduction: P-glycoprotein (P-gp)/ABCB1 and breast cancer resistance protein
(BCRP)/ABCG2 are highly expressed in the placenta and fetus throughout gestation and …

Background: Patients with preeclampsia display a spectrum of onset time and severity of
clinical presentation, yet the underlying molecular bases for the early-onset and late-onset …

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters are highly expressed in
tumor cells, as well as in organs involved in absorption and secretion processes, mediating …

Some women take medication during pregnancy to address a variety of clinical conditions.
Because of ethical and logistical concerns, it is impossible to determine fetal drug exposure …