Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease–associated genes
A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …
contribution of each variant to disease mechanism remains largely unknown. We have …
State of the art and prospects of methods for determination of lipophilicity of chemical compounds
D Kempińska, T Chmiel, A Kot-Wasik, A Mróz… - TrAC Trends in …, 2019 - Elsevier
Lipophilicity of the compounds is useful to (i) explain their distribution in biological systems,
which is different in plant and in animal organisms,(ii) predict the possible pathways of …
which is different in plant and in animal organisms,(ii) predict the possible pathways of …
Application of biomimetic HPLC to estimate lipophilicity, protein and phospholipid binding of potential peptide therapeutics
K Valko, G Ivanova-Berndt, P Beswick, M Kindey… - ADMET and …, 2018 - hrcak.srce.hr
Sažetak Peptide therapeutics are new modalities offering several challenges to drug
discovery. They are generally less stable and permeable in vivo. The characterization of …
discovery. They are generally less stable and permeable in vivo. The characterization of …
Characterization of the new CelerisTM arginine column: Retentive behaviour through a combination of chemometric tools and potential in drug analysis
G Russo, M Vallaro, L Cappelli, S Anderson… - … of Chromatography A, 2021 - Elsevier
Abstract Celeris TM Arginine (ARG) is a mixed-mode stationary phase recently released on
the market. To characterize its analytical behavior, the retention factors of a pool (n= 100, of …
the market. To characterize its analytical behavior, the retention factors of a pool (n= 100, of …
[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease …
A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …
contribution of each variant to disease mechanism remains largely unknown. We have …
Chromatographic HILIC indexes to characterize the lipophilicity of zwitterions
Reverse phase high pressure liquid chromatography (RP-HPLC) is widely employed in drug
discovery for lipophilicity measurements. Hydrophilic interaction liquid chromatography …
discovery for lipophilicity measurements. Hydrophilic interaction liquid chromatography …