Fluorine-containing drugs approved by the FDA in 2021

J He, Z Li, G Dhawan, W Zhang, AE Sorochinsky… - Chinese Chemical …, 2023 - Elsevier
Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …

Chemistry and pharmacology of fluorinated drugs approved by the FDA (2016–2022)

G Shabir, A Saeed, W Zahid, F Naseer, Z Riaz… - Pharmaceuticals, 2023 - mdpi.com
Fluorine is characterized by high electronegativity and small atomic size, which provide this
molecule with the unique property of augmenting the potency, selectivity, metabolic stability …

Cu-mediated Ullmann-type cross-coupling and industrial applications in route design, process development, and scale-up of pharmaceutical and agrochemical …

Q Yang, Y Zhao, D Ma - Organic Process Research & …, 2022 - ACS Publications
Cu-mediated Ullmann-type cross-coupling has experienced significant advances over the
last century since the seminal publication by Ullmann in 1901. These advances have …

Palladium‐Catalyzed Carbonylative Multicomponent Fluoroalkylation of 1, 3‐Enynes: Concise Construction of Diverse Cyclic Compounds

CS Kuai, BH Teng, XF Wu - Angewandte Chemie International …, 2024 - Wiley Online Library
Multicomponent reactions, particularly those entailing four or more reagents, have presented
a longstanding challenge due to the inherent complexities associated with balancing …

Recent developments in fluorine‐containing pesticides

P Jeschke - Pest Management Science, 2024 - Wiley Online Library
To ensure ongoing sustainability, the modern agrochemical industry is faced with enormous
challenges. These arise from provision of high‐quality food to increasing water use and …

Catalytic Diversification of gem‐Difluorocyclopropanes: Recent Advances and Challenges

L Lv, H Qian, Z Li - ChemCatChem, 2022 - Wiley Online Library
Abstract gem‐Difluorocyclopropanes (F2CPs) have aroused considerable attention not only
from the structural perspective but also due to their ability to participate in various valuable …

Modern approaches for the development of new herbicides based on natural compounds

A Berestetskiy - Plants, 2023 - mdpi.com
Weeds are a permanent component of anthropogenic ecosystems. They require strict control
to avoid the accumulation of their long-lasting seeds in the soil. With high crop infestation …

Finding fluorine: Photoproduct formation during the photolysis of fluorinated pesticides

AP Bhat, WCK Pomerantz… - Environmental Science & …, 2022 - ACS Publications
The photolysis of pesticides with different fluorine motifs was evaluated to quantify the
formation of fluorinated products in buffered aqueous systems, advanced oxidation (AOP) …

Copper-Mediated Cyanodifluoromethylation of (Hetero)aryl Iodides and Activated (Hetero)aryl Bromides with TMSCF2CN

J Nicolai, T Fantoni, TW Butcher, SI Arlow… - Journal of the …, 2024 - ACS Publications
Molecules bearing fluorine are increasingly prevalent in pharmaceuticals, agrochemicals,
and functional materials. The cyanodifluoromethyl group is unique because its size is closer …

Wavelength-dependent UV-LED photolysis of fluorinated pesticides and pharmaceuticals

AP Bhat, WCK Pomerantz… - Environmental Science & …, 2023 - ACS Publications
The wavelength dependence of photoproduct formation and quantum yields was evaluated
for fluorinated pesticides and pharmaceuticals using UV-light emitting diodes (LEDs) with …