[HTML][HTML] The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
Autoimmune psychosis: an international consensus on an approach to the diagnosis and management of psychosis of suspected autoimmune origin
There is increasing recognition in the neurological and psychiatric literature of patients with
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …
so-called isolated psychotic presentations (ie, with no, or minimal, neurological features) …
Association of birth during the COVID-19 pandemic with neurodevelopmental status at 6 months in infants with and without in utero exposure to maternal SARS-CoV-2 …
Importance Associations between in utero exposure to maternal SARS-CoV-2 infection and
neurodevelopment are speculated, but currently unknown. Objective To examine the …
neurodevelopment are speculated, but currently unknown. Objective To examine the …
[HTML][HTML] Causal role of immune cells in schizophrenia: Mendelian randomization (MR) study
C Wang, D Zhu, D Zhang, X Zuo, L Yao, T Liu, X Ge… - BMC psychiatry, 2023 - Springer
Background Complex immune-brain interactions that affect neural development, survival
and function might have causal and therapeutic implications for psychiatric illnesses …
and function might have causal and therapeutic implications for psychiatric illnesses …
Alteration patterns of peripheral concentrations of cytokines and associated inflammatory proteins in acute and chronic stages of schizophrenia: a systematic review …
Background Immune system dysfunction is considered to play an aetiological role in
schizophrenia spectrum disorders, with substantial alterations in the concentrations of …
schizophrenia spectrum disorders, with substantial alterations in the concentrations of …
[HTML][HTML] The central nervous system and the gut microbiome
Neurodevelopment is a complex process governed by both intrinsic and extrinsic signals.
While historically studied by researching the brain, inputs from the periphery impact many …
While historically studied by researching the brain, inputs from the periphery impact many …
Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: a Mendelian randomization study
Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
[HTML][HTML] From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways
The human body hosts an enormous abundance and diversity of microbes, which perform a
range of essential and beneficial functions. Our appreciation of the importance of these …
range of essential and beneficial functions. Our appreciation of the importance of these …
The fetal origins of mental illness
BJS Al-Haddad, E Oler, B Armistead… - American journal of …, 2019 - Elsevier
The impact of infections and inflammation during pregnancy on the developing fetal brain
remains incompletely defined, with important clinical and research gaps. Although the …
remains incompletely defined, with important clinical and research gaps. Although the …
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment
GM Khandaker, L Cousins, J Deakin… - The Lancet …, 2015 - thelancet.com
Complex interactions between the immune system and the brain might have important
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …
aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible …