Illuminating the druggable genome: Pathways to progress
KR Sharma, CM Colvis, GP Rodgers, DM Sheeley - Drug discovery today, 2023 - Elsevier
There are∼ 4500 genes within the 'druggable genome', the subset of the human genome
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …
[HTML][HTML] Polydextrose alleviates adipose tissue inflammation and modulates the gut microbiota in high-fat diet-fed mice
Q Hu, Y Niu, Y Yang, Q Mao, Y Lu, H Ran… - Frontiers in …, 2022 - frontiersin.org
The soluble dietary fiber polydextrose (PDX) is a randomly linked glucose oligomer
containing small amounts of sorbitol and citric acid and is widely used in the food industry …
containing small amounts of sorbitol and citric acid and is widely used in the food industry …
[HTML][HTML] Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics
Background Peripheral neuropathy (PN) is a common complication in obesity, prediabetes,
and type 2 diabetes, though its pathogenesis remains incompletely understood. In a murine …
and type 2 diabetes, though its pathogenesis remains incompletely understood. In a murine …
[HTML][HTML] Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases
H LIU, X LIU, J Xie, S Chen - Food Science and Technology, 2023 - SciELO Brasil
The feasibility of human nutritional supplementation is imperative. As a part of daily diet,
edible fungus polysaccharides have a variety of health promoting effects, especially for the …
edible fungus polysaccharides have a variety of health promoting effects, especially for the …
Effects of aerobic exercise on the regulation of mitochondrial carrier homolog-2 and its influence on the catabolic and anabolic activity of lipids in the mesenteric …
DG de Melo, VC da Cruz Rodrigues, GJ de Sá Pereira… - Life Sciences, 2024 - Elsevier
The aim was to understand the direct impact of aerobic short-term exercise on lipid
metabolism, specifically in regulating the mitochondrial carrier homolog 2 (MTCH2) and how …
metabolism, specifically in regulating the mitochondrial carrier homolog 2 (MTCH2) and how …
Onchidium struma polysaccharides exhibit hypoglycemic activity and modulate the gut microbiota in mice with type 2 diabetes mellitus
Y Zhao, P Song, S Yin, T Fan, F Li, X Ge, T Liu, W Xu… - Food & Function, 2023 - pubs.rsc.org
Onchidium struma polysaccharides (OsPs) are natural biologically active compounds, and
our previous work showed that they can inhibit the activity of α-glucosidase in vitro, showing …
our previous work showed that they can inhibit the activity of α-glucosidase in vitro, showing …
Vinyl chloride enhances high-fat diet-induced proteome alterations in the mouse pancreas related to metabolic dysfunction
Y Ge, M Bruno, MS Nash, NH Coates… - Toxicological …, 2023 - academic.oup.com
Alterations in physiological processes in pancreas have been associated with various
metabolic dysfunctions and can result from environmental exposures, such as chemicals …
metabolic dysfunctions and can result from environmental exposures, such as chemicals …
Metabolic and Skeletal Characterization of the KK/Ay Mouse Model—A Polygenic Mutation Model of Obese Type 2 Diabetes
Abstract Type 2 diabetes (T2D) increases fracture incidence and fracture-related mortality
rates (KK. Cg-Ay/J. The Jackson Laboratory; Available from: https://www. jax …
rates (KK. Cg-Ay/J. The Jackson Laboratory; Available from: https://www. jax …
[HTML][HTML] Alterations in inflammatory cytokines and redox homeostasis in LPS-induced pancreatic Beta-cell toxicity and mitochondrial stress: protection by Azadirachtin
A John, H Raza - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Inflammation and redox imbalance are hallmarks of cancer, diabetes, and other
degenerative disorders. Pathophysiological response to these disorders leads to oxidative …
degenerative disorders. Pathophysiological response to these disorders leads to oxidative …
Discriminating Metabolic Health Status in a Cohort of Nursing Students: A Cross-Sectional Study
S Lowes - 2023 - search.proquest.com
Nurses have a vital role in counselling their patients towards healthier living. However,
nurses tend to have poor metabolic health that may be influenced by lifestyle. Whether this …
nurses tend to have poor metabolic health that may be influenced by lifestyle. Whether this …