Comparative physiology of nociception and pain

LU Sneddon - Physiology, 2017 - journals.physiology.org
The study of diverse animal groups allows us to discern the evolution of the neurobiology of
nociception. Nociception functions as an important alarm system alerting the individual to …

Evolution of nociception and pain: evidence from fish models

LU Sneddon - … Transactions of the Royal Society B, 2019 - royalsocietypublishing.org
In order to survive, animals must avoid injury and be able to detect potentially damaging
stimuli via nociceptive mechanisms. If the injury is accompanied by a negative affective …

[HTML][HTML] Assessment of pain and inflammation in domestic animals using infrared thermography: a narrative review

AL Whittaker, R Muns, D Wang, J Martínez-Burnes… - Animals, 2023 - mdpi.com
Simple Summary Current acute pain assessment protocols in domestic animals require the
use of a suite of methods to evaluate the multidimensional components of pain. Thermal …

[HTML][HTML] Let thy food be thy medicine…. when possible

RF Witkamp, K van Norren - European journal of pharmacology, 2018 - Elsevier
There is no evidence that Hippocrates, although being credited for it, ever literally stated 'let
thy food be thy medicine and thy medicine be thy food'. However, yet in line with …

Ion channels as therapeutic antibody targets

CJ Hutchings, P Colussi, TG Clark - MAbs, 2019 - Taylor & Francis
It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …

Neuroinflammation, oxidative stress and their interplay in neuropathic pain: Focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential …

L Teixeira-Santos, A Albino-Teixeira, D Pinho - Pharmacological Research, 2020 - Elsevier
Neuropathic pain (NP) is a chronic condition that results from a lesion or disease of the
nervous system, greatly impacting patients' quality of life. Current pharmacotherapy options …

[HTML][HTML] Suppression of TRPV1/TRPM8/P2Y nociceptors by withametelin via downregulating MAPK signaling in mouse model of vincristine-induced neuropathic pain

A Khan, B Shal, AU Khan, R Ullah, MW Baig… - International journal of …, 2021 - mdpi.com
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …

Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain

A Uniyal, A Gadepalli, V Tiwari, M Allani, D Chouhan… - Life Sciences, 2022 - Elsevier
Chemotherapy-induced neuropathic pain (CINP) is among the most common clinical
complications associated with the use of anti-cancer drugs. CINP occurs in nearly 68.1% of …

[HTML][HTML] Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy

B Lin, Y Wang, P Zhang, Y Yuan, Y Zhang… - The journal of headache …, 2020 - Springer
Neuropathic pain (NP) is a sustained and nonreversible condition characterized by long-
term devastating physical and psychological damage. Therefore, it is urgent to identify an …

Localized neuropathic pain: an expert consensus on local treatments

G Pickering, E Martin, F Tiberghien… - Drug Design …, 2017 - Taylor & Francis
Background Pain localization is one of the hallmarks for the choice of first-line treatment in
neuropathic pain. This literature review has been conducted to provide an overview of the …