Haloperidol‐induced catalepsy as an animal model for parkinsonism: A systematic review of experimental studies

I Waku, MS Magalhaes, CO Alves… - European Journal of …, 2021 - Wiley Online Library
Several useful animal models for parkinsonism have been developed so far. Haloperidol‐
induced catalepsy is often used as a rodent model for the study of motor impairments …

Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

D Masini, O Kiehn - Nature communications, 2022 - nature.com
The pedunculopontine nucleus (PPN) is a locomotor command area containing
glutamatergic neurons that control locomotor initiation and maintenance. These motor …

Lipid nanocarrier of selegiline augmented anti-Parkinson's effect via P-gp modulation using quercetin

Z Qamar, MU Ashhar, FF Qizilibash, PK Sahoo… - International Journal of …, 2021 - Elsevier
In the present study, SEL was loaded in a lipid nanocarrier (LNC) formulation with a P-gp
pump inhibitor ie, Quercetin (QUR) for improving the bioavailability of the SEL in the brain …

In vivo Probabilistic Structural Atlas of the Inferior and Superior Colliculi, Medial and Lateral Geniculate Nuclei and Superior Olivary Complex in Humans Based on 7 …

MG García-Gomar, C Strong, N Toschi… - Frontiers in …, 2019 - frontiersin.org
Despite extensive neuroimaging research of primary sensory cortices involved in auditory
and visual functions, subcortical structures within these domains, such as the inferior and …

Deep cerebellar stimulation reduces ataxic motor symptoms in the shaker rat

CJ Anderson, KP Figueroa, AD Dorval… - Annals of …, 2019 - Wiley Online Library
Objective Degenerative cerebellar ataxias (DCAs) affect up to 1 in 5,000 people worldwide,
leading to incoordination, tremor, and falls. Loss of Purkinje cells, nearly universal across …

Paradoxical kinesia may no longer be a paradox waiting for 100 years to be unraveled

L Melo-Thomas, RKW Schwarting - Reviews in the Neurosciences, 2023 - degruyter.com
Parkinson's disease (PD) is a progressive neurodegenerative disorder mainly characterized
by bradykinesia and akinesia. Interestingly, these motor disabilities can depend on the …

Cortical neurostimulation and N-methyl-D-aspartate glutamatergic receptor activation in the dysgranular layer of the posterior insular cortex modulate chronic …

RCM Pereira, P Medeiros, NC Coimbra… - … : Technology at the …, 2023 - Elsevier
Abstract Background and Aims The dysgranula parts of the posterior insular cortex (PIC)
stimulation (PICS) has been investigated as a new putative cortical target for …

Predictive accuracy of CNN for cortical oscillatory activity in an acute rat model of parkinsonism

AAN Ali, M Alam, SC Klein, N Behmann, JK Krauss… - Neural Networks, 2022 - Elsevier
In neurological and neuropsychiatric disorders neuronal oscillatory activity between basal
ganglia and cortical circuits are altered, which may be useful as biomarker for adaptive deep …

Low frequency deep brain stimulation in the inferior colliculus ameliorates haloperidol-induced catalepsy and reduces anxiety in rats

H Ihme, RKW Schwarting, L Melo-Thomas - PLoS One, 2020 - journals.plos.org
Deep brain stimulation (DBS) of the colliculus inferior (IC) improves haloperidol-induced
catalepsy and induces paradoxal kinesia in rats. Since the IC is part of the brain aversive …

Lateralization in Hemiparkinsonian Rats Is Affected by either Deep Brain Stimulation or Glutamatergic Neurotransmission in the Inferior Colliculus

L Melo-Thomas, L Tacken, N Richter, D de Almeida… - Eneuro, 2022 - eneuro.org
After unilateral lesion of the medial forebrain bundle by 6-OHDA rats exhibit lateralized
deficits in spontaneous behavior or apomorphine-induced rotations. We investigated …