Control of protein levels by nucleic-acid-based technologies has proven to be a useful
research tool but lacks the advantages of small molecules with respect to cell permeability …

The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19
pandemic, bring new waves of infection worldwide. Identification of effective therapeutic …

Abstract Background Ubiquitin E3 ligase CUL4A plays important oncogenic roles in the
development of cancers. DTL, one of the CUL4-DDB1 associated factors (DCAFs), may …

Aim: Persistent activation of STING pathway is the basis for several autoimmune diseases.
STING is activated by cGAMP, which is produced by cGAS in the presence of DNA …

The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge …

Protein neddylation is a post-translational modification which transfers the ubiquitin-like
protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic …

Abstract IFN regulatory factor 3 (IRF3) is critical for the transcription of type I IFNs in
defensing virus and promoting inflammatory responses. Although several kinds of …

Ubiquitination is a multi-step enzymatic process that involves the marking of a substrate
protein by bonding a ubiquitin and protein for proteolytic degradation mainly via the ubiquitin …

The emergence of fast-spreading SARS-CoV-2 mutants has sparked a new phase of COVID-
19 pandemic. There is a dire necessity for antivirals targeting highly conserved genomic …

The ubiquitin-proteasome system (UPS) plays a central role in the degradation of cellular
proteins. Targeting protein degradation has been validated as an effective strategy for …