Huntington's disease (HD) is a progressive, fatal neurological condition caused by an
expansion of CAG (glutamine) repeats in the coding region of the Huntington gene. To date …

Huntington's disease (HD) is caused by an expansion of cytosine–adenine–guanine (CAG)
repeats in the huntingtin gene, which leads to neuronal loss in the striatum and cortex and to …

Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

N-methyl-D-aspartate receptor (NMDAR) excitotoxicity is implicated in the pathogenesis of
Huntington's disease (HD), a late-onset neurodegenerative disorder. However, NMDARs …

Investigations of synaptic transmission and plasticity in mouse models of Huntington's
disease (HD) demonstrate neuronal dysfunction long before the onset of classical disease …

Huntington's disease (HD) is an autosomal neurodegenerative disorder, characterized by
severe behavioral, cognitive, and motor deficits. Since the discovery of the huntingtin gene …

Glial cells play critical roles in the normal development and function of neural circuits, but in
many neurodegenerative diseases, they become dysregulated and may contribute to the …

Research over the last few decades has shaped our understanding of the crucial
involvement of the N-methyl-d-aspartate receptor (NMDAR) in mediating excitatory synaptic …

Abstract N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is
involved in learning and memory processes. Yet, the impact of a dysregulation of post …

The tri-nucleotide repeat expansion underlying Huntington disease (HD) results in
corticostriatal synaptic dysfunction and subsequent neurodegeneration of striatal medium …