Targeting epigenetic regulators to overcome drug resistance in cancers

N Wang, T Ma, B Yu - Signal transduction and targeted therapy, 2023 - nature.com
Drug resistance is mainly responsible for cancer recurrence and poor prognosis. Epigenetic
regulation is a heritable change in gene expressions independent of nucleotide sequence …

[HTML][HTML] Non-coding RNA-mediated modulation of ferroptosis in cardiovascular diseases

Y Liu, W Ding, J Wang, X Ao, J Xue - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality
worldwide and seriously threatens human health and life. Cardiomyocyte death is …

Non-coding RNAs in lung cancer: molecular mechanisms and clinical applications

Y Liu, W Ding, J Wang, X Ao, J Xue - Frontiers in oncology, 2023 - frontiersin.org
Lung cancer (LC) is a heterogeneous disease with high malignant degree, rapid growth,
and early metastasis. The clinical outcomes of LC patients are generally poor due to the …

The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Y Zhang, W Yu, M Chen, B Zhang, L Zhang, P Li - Nanoscale, 2023 - pubs.rsc.org
Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes,
and they have recently been collectively identified as a class of innovative artificial enzymes …

Cancer chemoresistance and its mechanisms: Associated molecular factors and its regulatory role

S Kannampuzha, AV Gopalakrishnan - Medical Oncology, 2023 - Springer
Cancer therapy has advanced from tradition chemotherapy methods to targeted therapy,
novel drug delivery mechanisms, combination therapies etc. Although several novel …

Copper and diabetes: current research and prospect

W Chang, P Li - Molecular Nutrition & Food Research, 2023 - Wiley Online Library
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …

The critical roles of m6A RNA methylation in lung cancer: from mechanism to prognosis and therapy

MN Diao, XJ Zhang, YF Zhang - British Journal of Cancer, 2023 - nature.com
Lung cancer, a highly malignant disease, greatly affects patients' quality of life. N6-
methyladenosine (m6A) is one of the most common posttranscriptional modifications of …

[HTML][HTML] Epigenetic modifications: Key players in cancer heterogeneity and drug resistance

HQ Sadida, A Abdulla, S Al Marzooqi, S Hashem… - Translational …, 2024 - Elsevier
Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer
treatment and management. One major contributor to these challenges is epigenetic …

The important regulatory roles of circRNA-encoded proteins or peptides in cancer pathogenesis

L Zhang, H Gao, X Li, F Yu, P Li - … Journal of Oncology, 2023 - spandidos-publications.com
Circular RNAs (circRNAs) represent a class of RNA molecules characterized by their
covalently closed structures. There are three types of circRNAs, namely exonic circRNAs …

[HTML][HTML] Dysregulation of different modes of programmed cell death by epigenetic modifications and their role in cancer

R Damiescu, T Efferth, M Dawood - Cancer Letters, 2024 - Elsevier
Modifications of epigenetic factors affect our lives and can give important information
regarding one's state of health. In cancer, epigenetic modifications play a crucial role, as …