[PDF][PDF] Review on epidermal growth factor receptor (EGFR) structure, signaling pathways, interactions, and recent updates of EGFR inhibitors

DA Sabbah, R Hajjo, K Sweidan - Current topics in medicinal …, 2020 - researchgate.net
The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …

FGF receptors: cancer biology and therapeutics

M Katoh, H Nakagama - Medicinal research reviews, 2014 - Wiley Online Library
Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

[HTML][HTML] Nanoparticle-based drug delivery systems targeting cancer cell surfaces

L Hong, W Li, Y Li, S Yin - RSC advances, 2023 - pubs.rsc.org
Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …

Review on EGFR inhibitors: critical updates

D Singh, BK Attri, RK Gill… - Mini reviews in medicinal …, 2016 - ingentaconnect.com
Epidermal Growth Factor Receptor (EGFR) is a transmembrane glycoprotein that constitutes
one of the four members of ErbB family of tyrosine kinase receptors. Activation of EGFR …

Development of hypoxia-activated PROTAC exerting a more potent effect in tumor hypoxia than in normoxia

W Cheng, S Li, X Wen, S Han, S Wang, H Wei… - Chemical …, 2021 - pubs.rsc.org
Hypoxia is a hallmark of many solid tumors, and it causes the overexpression of a variety of
proteins including the epidermal growth factor receptor (EGFR). Many antitumor prodrugs …

[HTML][HTML] STAT3 as a target for inducing apoptosis in solid and hematological tumors

K Al Zaid Siddiquee, J Turkson - Cell research, 2008 - nature.com
Studies in the past few years have provided compelling evidence for the critical role of
aberrant Signal Transducer and Activator of Transcription 3 (STAT3) in malignant …

Therapeutic progression of quinazolines as targeted chemotherapeutic agents

R Bansal, A Malhotra - European Journal of Medicinal Chemistry, 2021 - Elsevier
Presently cancer is a grave health issue with predominance beyond restrictions. It can affect
any organ of the body. Most of the available chemotherapeutic drugs are highly toxic, not …

Antitumoral activity of snake venom proteins: new trends in cancer therapy

LA Calderon, JC Sobrinho, KD Zaqueo… - BioMed research …, 2014 - Wiley Online Library
For more than half a century, cytotoxic agents have been investigated as a possible
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …

The anticancer effect of probiotic Bacillus polyfermenticus on human colon cancer cells is mediated through ErbB2 and ErbB3 inhibition

EL Ma, YJ Choi, J Choi, C Pothoulakis… - … journal of cancer, 2010 - Wiley Online Library
A wealth of data implicates that ErbB receptors have essential roles in tumor development.
Probiotic bacteria are known to exert an anticancer activity in animal studies. Bacillus …

Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives

FM Chen, RM Shelton, Y Jin… - Medicinal Research …, 2009 - Wiley Online Library
Difficulties associated with achieving predictable periodontal regeneration, means that novel
techniques need to be developed in order to regenerate the extensive soft and hard tissue …