Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …

Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Cancer-associated fibroblast (CAF) heterogeneity is increasingly appreciated, but the
origins and functions of distinct CAF subtypes remain poorly understood. The abundant and …

Histones are DNA‐binding basic proteins found in chromosomes. After the histone
translation, its amino tail undergoes various modifications, such as methylation, acetylation …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

Sirtuin proteins regulate diverse cellular pathways that influence genomic stability,
metabolism and ageing,. SIRT7 is a mammalian sirtuin whose biochemical activity …

Digestive cancers are the leading cause of cancer-related death worldwide and have high
risks of morbidity and mortality. Histone methylation, which is mediated mainly by lysine …

p300 and CREB-binding protein (CBP), two homologous lysine acetyltransferases in
metazoans, have a myriad of cellular functions. They exert their influence mainly through …

The genetic changes leading to the development of human cancer are accompanied by
alterations in the structure and modification status of chromatin, which represent powerful …

Resistance of cancer cells to chemotherapeutics and emerging targeted drugs is a
devastating problem in the treatment of cancer patients. Multiple mechanisms contribute to …