Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Familial hypercholesterolemia (FH) is an autosomal dominant condition that leads to
significantly elevated low-density lipoprotein cholesterol (LDL-C) levels and an elevated risk …

Primary hyperlipidemias include a heterogeneous set of monogenic and polygenic
conditions characterized by a strong family aggregation, severe forms of …

Introduction Familial hypercholesterolemia is a genetic disorder characterized by elevated
levels of low-density lipoprotein cholesterol (LDL-C) since birth and an exceedingly high risk …

Accumulating observational studies suggested that hypercholesterolemia is associated with
vascular dementia (VaD); however, the causality between them remains unclear. Hence, the …

Familial hypercholesterolemia (FH) is a hereditary disorder that causes severely elevated
low-density lipoprotein (LDL-C) levels, which leads to an increased risk for premature …

Dyslipidemia plays a fundamental role in the development and progression of
atherosclerosis. Current guidelines for treating dyslipidemia focus on low-density lipoprotein …

Familial hypercholesterolemia (FH), a condition, which is characterized by a life-long
exposure to markedly elevated low-density lipoprotein (LDL) concentrations from birth, and it …

Apolipoprotein B (ApoB) is the primary component of atherogenic lipoproteins, which
transport serum fats and cholesterol. Therefore elevated levels of circulating ApoB are a …

Antisense oligonucleotides (ASOs) are single stranded nucleic acids that target RNA. The
US Food and Drug Administration has approved ASOs for several diseases. ASOs utilize …