Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections

CE James, EV Davies, JL Fothergill… - The ISME …, 2015 - academic.oup.com
Pseudomonas aeruginosa is the most common bacterial pathogen infecting the lungs of
cystic fibrosis (CF) patients. The transmissible Liverpool epidemic strain (LES) harbours …

[HTML][HTML] The potential of phage therapy in cystic fibrosis: Essential human-bacterial-phage interactions and delivery considerations for use in Pseudomonas …

S Trend, AM Fonceca, WG Ditcham, A Kicic… - Journal of Cystic Fibrosis, 2017 - Elsevier
As antimicrobial-resistant microbes become increasingly common and a significant global
issue, novel approaches to treating these infections particularly in those at high risk are …

Why? – Successful Pseudomonas aeruginosa clones with a focus on clone C

C Lee, J Klockgether, S Fischer, J Trcek… - FEMS microbiology …, 2020 - academic.oup.com
The environmental species Pseudomonas aeruginosa thrives in a variety of habitats. Within
the epidemic population structure of P. aeruginosa, occassionally highly successful clones …

Filamentous prophage Pf4 promotes genetic exchange in Pseudomonas aeruginosa

TT Pei, H Luo, Y Wang, H Li, XY Wang… - The ISME …, 2024 - academic.oup.com
Filamentous prophages are widespread among bacteria and play crucial functions in
virulence, antibiotic resistance, and biofilm structures. The filamentous Pf4 particles …

Mechanistic analysis of a synthetic inhibitor of the Pseudomonas aeruginosa LasI quorum-sensing signal synthase

O Lidor, A Al-Quntar, EC Pesci, D Steinberg - Scientific reports, 2015 - nature.com
Pseudomonas aeruginosa is an opportunistic Gram-negative pathogen responsible for
many human infections. LasI is an acyl-homoserine lactone synthase that produces a …

[HTML][HTML] Persistence and genetic adaptation of Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease

J Eklöf, MA Misiakou, P Sivapalan, K Armbruster… - Clinical Microbiology …, 2022 - Elsevier
Objectives It is unclear whether recurrent sputum culture with Pseudomonas aeruginosa
from patients with chronic obstructive pulmonary disease (COPD) is caused by intermittent …

The problems of antibiotic resistance in cystic fibrosis and solutions

C López-Causapé, E Rojo-Molinero… - Expert review of …, 2015 - Taylor & Francis
Chronic respiratory infection is the main cause of morbidity and mortality in cystic fibrosis
(CF) patients. One of the hallmarks of these infections, led by the opportunistic pathogen …

Omics-based tracking of Pseudomonas aeruginosa persistence in “eradicated” cystic fibrosis patients

JA Bartell, LM Sommer, RL Marvig… - European …, 2021 - Eur Respiratory Soc
Whenever Pseudomonas aeruginosa is cultured from cystic fibrosis (CF) patient airways, the
primary goal is eradication by antibiotic therapy. Success is defined by≥ 6 months of …

Epidemiology of infection and current guidelines for infection prevention in cystic fibrosis patients

K Schaffer - Journal of Hospital Infection, 2015 - Elsevier
The spectrum of bacterial pathogens encountered in cystic fibrosis (CF) lung disease has
expanded over the last decade. In addition to established pathogens, such as …

Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms

G Giallonardi, M Letizia, M Mellini… - Frontiers in Cellular …, 2023 - frontiersin.org
Pseudomonas aeruginosa is a model quorum sensing (QS) pathogen with three
interconnected QS circuits that control the production of virulence factors and antibiotic …