Role of inflammatory chemokines in hypertension

TP Mikolajczyk, P Szczepaniak, F Vidler… - Pharmacology & …, 2021 - Elsevier
Hypertension is associated with immune cells activation and their migration into the kidney,
vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure …

A survey of gene prioritization tools for Mendelian and complex human diseases

O Zolotareva, M Kleine - Journal of integrative bioinformatics, 2019 - degruyter.com
Modern high-throughput experiments provide us with numerous potential associations
between genes and diseases. Experimental validation of all the discovered associations, let …

Identification of Comorbidities, Genomic Associations, and Molecular Mechanisms for COVID‐19 Using Bioinformatics Approaches

SBS Omit, S Akhter, HK Rana… - BioMed Research …, 2023 - Wiley Online Library
Several studies have been done to identify comorbidities of COVID‐19. In this work, we
developed an analytical bioinformatics framework to reveal COVID‐19 comorbidities, their …

Comorbidity of asthma and hypertension may be mediated by shared genetic dysregulation and drug side effects

O Zolotareva, OV Saik, C Königs, EY Bragina… - Scientific reports, 2019 - nature.com
Asthma and hypertension are complex diseases coinciding more frequently than expected
by chance. Unraveling the mechanisms of comorbidity of asthma and hypertension is …

The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease

X Liu, X Huang, F Xu - BMC Pulmonary Medicine, 2023 - Springer
Increasing evidences have demonstrated that pyroptosis exerts key roles in the occurrence,
development of chronic obstructive pulmonary disease. However, the mechanisms of …

[PDF][PDF] Establishment of a diagnostic model based on immune-related genes in children with asthma

Y Yuan, H Zhu, S Huang, Y Zhang, Y Shen - Heliyon, 2024 - cell.com
Objective Allergic asthma is driven by an antigen-specific immune response. This study
aimed to identify immune-related differentially expressed genes in childhood asthma and …

[HTML][HTML] Reconstruction and analysis of the gene regulatory network for cell wall function in Arabidopsis thaliana L. leaves in response to water deficit

AR Volyanskaya, EA Antropova… - Vavilov Journal of …, 2023 - ncbi.nlm.nih.gov
The plant cell wall represents the outer compartment of the plant cell, which provides a
physical barrier and triggers signaling cascades under the influence of biotic and abiotic …

Identification of differentially expressed gene modules in heterogeneous diseases

O Zolotareva, S Khakabimamaghani, OI Isaeva… - …, 2021 - academic.oup.com
Motivation Identification of differentially expressed genes is necessary for unraveling
disease pathogenesis. This task is complicated by the fact that many diseases are …

[HTML][HTML] Molecular-genetic pathways of hepatitis C virus regulation of the expression of cellular factors PREB and PLA2G4C, which play an important role in virus …

EL Mishchenko, AA Makarova… - Vavilov Journal of …, 2023 - ncbi.nlm.nih.gov
The participants of Hepatitis C virus (HCV) replication are both viral and host proteins.
Therapeutic approaches based on activity inhibition of viral non-structural proteins NS3 …

[HTML][HTML] Prioritization of potential pharmacological targets for the development of anti-hepatocarcinoma drugs modulating the extrinsic apoptosis pathway: the …

PS Demenkov, EA Antropova… - Vavilov Journal of …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a common severe type of liver cancer characterized by
an extremely aggressive course and low survival rates. It is known that disruptions in the …