The rapidly declining prevalence of Helicobacter pylori infection and widespread use of
potent anti-secretory drugs means peptic ulcer disease has become substantially less …

The human diet and dietary patterns are closely linked to the health status. High-calorie
Western-style diets have increasingly come under scrutiny as their caloric load and …

Non-variceal upper gastrointestinal bleeding (NVUGIB) is bleeding that develops in the
oesophagus, stomach or proximal duodenum. Peptic ulcers, caused by Helicobacter pylori …

Background The role of gastric acid suppression in preventing the recurrence of ulcer
complications after the eradication of Helicobacter pylori infection in patients taking long …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are probably the most common cause of
gastroduodenal injury in the United States today. Approximately half of patients who …

OBJECTIVES: To discuss nonsteroidal anti-inflammatory drugs (NSAIDs), their history,
development, mode of action, toxicities, strategies for the prevention of toxicity, and future …

Curcumin, a major yellow pigment and active component of turmeric, has been shown to
possess anti-inflammatory and anti-cancer activities. Cyclooxygenase (COX)-2 plays an …

One of the hallmarks of the mammalian stomach is its ability to secrete large quantities of
concentrated (0.16 mol/L) hydrochloric acid (HCl). 1 Although it is generally assumed that …

Background In short-term trials, aspirin is associated with gastrointestinal bleeding.
However, the effect of dose and duration of aspirin use on risk remains unclear. Methods We …

Background: Aspirin is valuable for preventing vascular events, but information about ulcer
frequency is necessary to inform risk‐benefit decisions in individual patients. Aim: To …