Pathobiology of cognitive impairment in Parkinson disease: challenges and outlooks

KA Jellinger - International Journal of Molecular Sciences, 2023 - mdpi.com
Cognitive impairment (CI) is a characteristic non-motor feature of Parkinson disease (PD)
that poses a severe burden on the patients and caregivers, yet relatively little is known about …

[HTML][HTML] Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient selection and biomarkers

LL Gibson, C Abdelnour, J Chong… - Current Opinion in …, 2023 - journals.lww.com
Clinical trials in dementia with Lewy bodies: the evolving c... : Current Opinion in Neurology
Clinical trials in dementia with Lewy bodies: the evolving concept of co-pathologies, patient …

Occipital atrophy signature in prodromal Lewy bodies disease

A Galli, A Pilotto, B Chiarini, M Giunta… - Alzheimer's & …, 2023 - Wiley Online Library
INTRODUCTION Dementia with Lewy bodies (DLB) is typically characterized by parietal,
temporal, and occipital atrophy, but less is known about the newly defined prodromal …

Application of Suggestive Biomarkers in Dementia With Lewy Bodies With Masking of Typical Clinical Symptoms by Alzheimer Disease-type Pathology

R Kobayashi, D Morioka, S Kawakatsu… - Alzheimer Disease & …, 2024 - journals.lww.com
Dementia with Lewy bodies (DLB) is strongly associated with Alzheimer disease (AD)-type
pathology and tends to mask the core clinical features of DLB. Therefore, there may be …

[HTML][HTML] Identifying parkinsonism in mild cognitive impairment

R Fernando, AJ Thomas, CA Hamilton… - Journal of the …, 2024 - Elsevier
Introduction Clinical parkinsonism is a core diagnostic feature for mild cognitive impairment
with Lewy bodies (MCI-LB) but can be challenging to identify. A five-item scale derived from …

[HTML][HTML] Differentiating Prodromal Dementia with Lewy Bodies from Prodromal Alzheimer's Disease: A Pragmatic Review for Clinicians

KA Wyman-Chick, P Chaudhury, E Bayram… - Neurology and …, 2024 - Springer
This pragmatic review synthesises the current understanding of prodromal dementia with
Lewy bodies (pDLB) and prodromal Alzheimer's disease (pAD), including clinical …

Outcomes of Patients With Mild Cognitive Impairment With Lewy Bodies or Alzheimer Disease at 3 and 5 Years After Diagnosis

CA Hamilton, PC Donaghy, R Durcan, J Ciafone… - Neurology, 2024 - AAN Enterprises
Background and Objectives Retrospective studies indicate that dementia with Lewy bodies
(DLB) may be preceded by a mild cognitive impairment (MCI) prodrome. Research criteria …

Clinical presentations and diagnostic application of proposed biomarkers in psychiatric‐onset prodromal dementia with Lewy bodies

R Kobayashi, K Iwata‐Endo, H Fujishiro - Psychogeriatrics, 2024 - Wiley Online Library
Research criteria for the diagnosis of prodromal dementia with Lewy bodies (DLB) include
three clinical subtypes: mild cognitive impairment with Lewy bodies (MCI‐LB), delirium …

[HTML][HTML] Factors Associated With Increased Health Care Utilization for Patients With Dementia With Lewy Bodies: A Narrative Review

KA Wyman-Chick, MJ Barrett, MJ Miller… - Journal of Patient …, 2024 - ncbi.nlm.nih.gov
Numerous studies have demonstrated that dementia is associated with increased utilization
of health care services, which in turn results in increased costs of care. Dementia with Lewy …

In vivo detection of Alzheimer's and Lewy body disease concurrence: Clinical implications and future perspectives

S Baiardi, O Hansson, J Levin… - Alzheimer's & Dementia, 2024 - Wiley Online Library
INTRODUCTION The recent introduction of seed amplification assays (SAAs) detecting
misfolded α‐synuclein, a pathology‐specific marker for Lewy body disease (LBD), has …