Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

The translation of the growing increase of findings emerging from basic nutritional science
into meaningful and clinically relevant dietary advices represents nowadays one of the main …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Nowadays, obesity is one of the largest public health problems worldwide. In the last few
decades, there has been a marked increase in the obesity epidemic and its related …

Sex differences in adipose tissue distribution and the metabolic, endocrine, and immune
functions of different anatomical fat depots have been described, but they are incompletely …

Aging has been recognized to be a highly complex biological health problem with a high risk
of chronic diseases, including type 2 diabetes, atherosclerosis, chronic bronchitis or …

The global prevalence of metabolic disorders, such as obesity, diabetes and fatty liver
disease, is dramatically increasing. Both genetic and environmental factors are well-known …

Objective Human white adipose tissue (AT) is a metabolically active organ with distinct
depot-specific functions. Despite their locations close to the gastrointestinal tract, mesenteric …

Background There is considerable evidence for the importance of the DNA methylome in
metabolic health, for example, a robust methylation signature has been associated with …

Epigenetic processes that modulate gene expression but do not involve DNA sequence
changes can have a major impact on disease development, and perhaps the most important …