The overexpression of the human ATP-binding cassette (ABC) transporters in cancer cells is
a common mechanism involved in developing multidrug resistance (MDR). Unfortunately …

Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar
endo‐and xenobiotics in the human body, especially in the tissue barriers and the …

Tyrosine kinases (TKs) play an important role in pathways that regulate cancer cell
proliferation, apoptosis, angiogenesis and metastasis. Aberrant activity of TKs has been …

Mitochondrial drug delivery has attracted increasing attention in various mitochondrial
dysfunction-associated disorders such as cancer owing to the important role of energy …

Multidrug resistance (MDR) in cancer cells is a challenging phenomenon often associated
with P-glycoprotein (Pgp) surface expression. Finding new ways to bypass Pgp-mediated …

The frequent occurrence of multidrug resistance (MDR) conferred by the overexpression of
ATP-binding cassette (ABC) transporters ABCB1 and ABCG2 in cancer cells remains a …

Introduction: Osteosarcoma (OS), the most common primary malignant bone tumor, is
currently treated with pre-and postoperative chemotherapy in association with the surgical …

Drug efflux transporters, in particular P-glycoprotein (Pgp), limit the success of
chemotherapy. We previously found that synthetic doxorubicin conjugated with nitric oxide …

Nilotinib is a selective inhibitor of BCR-ABL approved for use in newly diagnosed and
imatinib-resistant or-intolerant patients with chronic myeloid leukemia (CML) in chronic …