Sterol regulatory element-binding proteins (SREBPs) are key transcription factors that
stimulate the expression of genes involved in fatty acid and cholesterol biosynthesis. Here …

Background Bile acids are potentially toxic compounds and their levels of hepatic
production, uptake and export are tightly regulated by many inputs, including circadian …

Beyond their role as emulsifiers of lipophilic compounds, bile acids (BAs) are signaling
endocrine molecules that show differential affinity and specificity for a variety of canonical …

Nuclear receptors (NRs) are conditional transcription factors with common multidomain
organization that bind diverse DNA elements. How DNA sequences influence NR …

The aim of the present study was to investigate the short-and long-term effects of a high-fat
Western diet (WD) on intake, storage, expenditure, and fecal loss of energy as well as effects …

PR domain-containing 16 (PRDM16) induces expression of brown fat-specific genes in
brown and beige adipocytes, although the underlying transcription-related mechanisms …

Although widely prescribed for their potent antiinflammatory actions, glucocorticoid drugs
(eg, dexamethasone) cause undesirable side effects that are features of the metabolic …

Objective To determine the effect of maternal obesity, gestational diabetes mellitus (GDM)
and adipokines on the expression of genes involved in fatty acid uptake, transport, synthesis …

Fatty liver and hepatic triglyceride accumulation are strongly associated with obesity, insulin
resistance and type 2 diabetes, and are subject to nutritional influences. Hepatic regulation …

The consumption and composition of food in daily life predict our health in long run. The
relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin …