Neuregulin 4 suppresses NASH-HCC development by restraining tumor-prone liver microenvironment
The mammalian liver comprises heterogeneous cell types within its tissue microenvironment
that undergo pathophysiological reprogramming in disease states, such as non-alcoholic …
that undergo pathophysiological reprogramming in disease states, such as non-alcoholic …
Post COVID-19 syndrome in patients with asymptomatic/mild form
A Malkova, I Kudryavtsev, A Starshinova, D Kudlay… - Pathogens, 2021 - mdpi.com
Post COVID-19 Syndrome (PCS) is a complex of various symptoms developing a month or
more after the acute phase of the disease. The cases of PCS development among patients …
more after the acute phase of the disease. The cases of PCS development among patients …
mTOR regulates T cell exhaustion and PD-1–targeted immunotherapy response during chronic viral infection
S Ando, CM Perkins, Y Sajiki… - The Journal of …, 2023 - Am Soc Clin Investig
T cell exhaustion is a state of T cell dysfunction associated with expression of programmed
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
death 1 (PD-1). Exhausted CD8+ T cells are maintained by self-renewing stem-like T cells …
Improving CAR T-cell persistence
V Pietrobon, LA Todd, A Goswami, O Stefanson… - International journal of …, 2021 - mdpi.com
Over the last decade remarkable progress has been made in enhancing the efficacy of CAR
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …
T therapies. However, the clinical benefits are still limited, especially in solid tumors. Even in …
Dendritic cell vaccination of glioblastoma: road to success or dead end
A Datsi, RV Sorg - Frontiers in Immunology, 2021 - frontiersin.org
Glioblastomas (GBM) are the most frequent and aggressive malignant primary brain tumor
and remains a therapeutic challenge: even after multimodal therapy, median survival of …
and remains a therapeutic challenge: even after multimodal therapy, median survival of …
A versatile CRISPR-Cas13d platform for multiplexed transcriptomic regulation and metabolic engineering in primary human T cells
CRISPR technologies have begun to revolutionize T cell therapies; however, conventional
CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To …
CRISPR-Cas9 genome-editing tools are limited in their safety, efficacy, and scope. To …
Single-cell profiling reveals unique features of diabetogenic T cells in anti-PD-1-induced type 1 diabetes mice
Immune-related adverse events (irAEs) are a notable complication of PD-1 cancer
immunotherapy. A better understanding of how these iatrogenic diseases compare with …
immunotherapy. A better understanding of how these iatrogenic diseases compare with …
Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 …
The hypoxic tumor microenvironment has been implicated in immune escape, but the
underlying mechanism remains elusive. Using an in vitro culture system modeling human T …
underlying mechanism remains elusive. Using an in vitro culture system modeling human T …
Regulation of CD8+ T memory and exhaustion by the mTOR signals
Y Chen, Z Xu, H Sun, X Ouyang, Y Han, H Yu… - Cellular & Molecular …, 2023 - nature.com
CD8+ T cells are the key executioners of the adaptive immune arm, which mediates
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …
antitumor and antiviral immunity. Naïve CD8+ T cells develop in the thymus and are quickly …
Immune responses to Toxoplasma gondii
IA Khan, M Moretto - Current opinion in immunology, 2022 - Elsevier
Highlights•Toxoplasma gondii evokes a strong innate and adaptive immune response in the
host.•Innate immunity to the parasite is comprised of many components like DC, neutrophils …
host.•Innate immunity to the parasite is comprised of many components like DC, neutrophils …