T cells are the key players in eliminating malignant tumors. Adoptive transfer of tumor
antigen-specific T cells and immune checkpoint blockade has yielded durable antitumor …

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other
suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction …

Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic
cell death by several mechanisms. Moreover, a prolonged and uncontrolled immune …

T cell dysfunctionality prevents the clearance of chronic infections and cancer. Furthermore,
epigenetic programming in dysfunctional CD8+ T cells limits their response to …

BACKGROUND Low-dose anti–thymocyte globulin (ATG) transiently preserves C-peptide
and lowers HbA1c in individuals with recent-onset type 1 diabetes (T1D); however, the …

Long-term antitumor efficacy of chimeric antigen receptor (CAR) T cells depends on their
functional persistence in vivo. T cells with stem-like properties show better persistence, but …

The complexity of the cellular and acellular players within the tumor microenvironment
(TME) allows for significant variation in TME constitution and role in anticancer treatment …

Following viral infection, the human immune system generates CD8+ T cell responses to
virus antigens that differ in specificity, abundance, and phenotype. A characterization of virus …

Cancer immunotherapy using immune-checkpoint inhibitors (ICIs) has revolutionized the
field of cancer treatment; however, ICI efficacy is constrained by progressive dysfunction of …

The standard therapies in lymphoma have predominantly focused on targeting tumor cells
with less of a focus on the tumor microenvironment (TME), which plays a critical role in …