In T-cell biology,'exhaustion'was initially described as a hyporesponsive state in CD8+ T
cells during chronic infections. Recently, exhaustion has been recognized as a T-cell …

The death rate from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infections in 2022 was lower than the death rate in 2021, when the infection rate increased …

The brain tumor microenvironment contains numerous distinct types of nonneoplastic cells,
which each serve a diverse set of roles relevant to the formation, maintenance, and …

We performed single-cell RNA-sequencing and T cell receptor clonotype tracking of breast
and ovarian cancer patients treated with the CDK4/6 inhibitor ribociclib and PD-1 blockade …

Human alveolar echinococcosis (AE) is a tumor-like disease predominantly located in the
liver. The cellular composition and heterogeneity of the lesion-infiltrating lymphocytes which …

Psoriasis is one of the most common inflammatory skin diseases with a chronic, relapsing-
remitting course. The last decades of intense research uncovered a pathological network of …

T cell exhaustion is a hallmark of hepatitis C virus (HCV) infection and limits protective
immunity in chronic viral infections and cancer. Limited knowledge exists of the initial viral …

Summary Background Anti-MDA5 (Melanoma differentiation-associated protein-5) positive
dermatomyositis (MDA5+-DM) is characterised by rapidly progressive interstitial lung …

Tumor cells exploit several mechanisms for hijacking an immunosuppressive tumor
ecosystem in order to evade immune surveillance and to progress toward metastasis …

Long-term immunological memory represents a unique performance of the adaptive
immunity selected during evolution to support long-term survival of species in vertebrates …