There is evidence that the orphan nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in
exhausted CD8+ T cells and regulates PD-L1 in tumors. This study investigated the effects of …

Multi-organ inflammatory diseases are one of the most serious autoimmune diseases
worldwide. The regulation of immune responses by immune checkpoint proteins influences …

Infection, autoimmunity, and cancer are principal human health challenges of the 21 st
century. Often regarded as distinct ends of the immunological spectrum, recent studies hint …

Dysregulated innate and adaptive immunity is a sign of SARS-CoV-2-induced disease and
cancer. CD8+ T cells are important cells of the immune system. The cells belong to the …

The differences between male and female immune systems are an under-researched field,
ripe for discovery. This is evidenced by the stark sex biases seen in autoimmunity and …

Intrahepatic macrophages in nonalcoholic steatohepatitis (NASH) are heterogenous and
include proinflammatory recruited monocyte-derived macrophages. The receptor for …

Currently, sarcoidosis remains one of the diseases with unknown etiology, which
significantly complicates its diagnosis and treatment. Various causes of sarcoidosis have …

The high recurrence rate of non-muscle invasive bladder cancer (BC) and poor prognosis of
advanced BC are therapeutic challenges that need to be solved. Bacillus Calmette-Guerin …

Rewiring exhausted CD8 T cells (TEX) towards more functional states is a major goal of
cancer immunotherapy but has proven challenging due to the epigenetic stability of TEX …

For decades, scientists have been investigating how processes such as gene expression,
stem cell plasticity, and cell differentiation can be modulated. The discovery of epigenetics …