Our understanding of COVID-19 vaccinations and their impact on health and mortality has
evolved substantially since the first vaccine rollouts. Published reports from the original …

Upon resolution of an acute viral infection, during latent‐reactivating infection and during
chronic active infections virus‐specific T‐cells differentiate into distinct subsets that differ in …

Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug
delivery. Herein, we report that small interfering RNA (siRNA) effectively coordinates with …

Abstract Immunotherapy, including PD-1/PD-L1 agonists, has shown limited efficacy in
pancreatic ductal adenocarcinoma (PDAC). We examined the PD-1/PD-L1 expression and …

CD8+ T cells are cytotoxic lymphocytes that destroy pathogen infected and malignant cells
through release of cytolytic molecules and proinflammatory cytokines. Although the role of …

T cells are endowed with the capacity to sense their environment including other T cells
around them. They do so to set their numbers and activation thresholds. This form of …

Background Crescentic GN (cGN) is an aggressive form of immune-mediated kidney
disease that is an important cause of end stage renal failure. Antineutrophilic cytoplasmic …

Sarcoidosis is an interstitial lung disease (ILD) characterized by interferon-γ (IFN-γ) and T-
box expressed in T cells (TBET) dysregulation. Although one-third of patients progress from …

Understanding the mechanisms that regulate T cell immunity is critical for the development
of effective therapies for diseases associated with T cell dysfunction, including autoimmune …

Background & Aims HBsAg secretion may impact immune responses to chronic HBV
infection. Thus, therapeutic approaches to suppress HBsAg production are being …