Although natural killer (NK) cells are recognized for their modulation of immune responses,
the mechanisms by which human NK cells mediate immune regulation are unclear. Here …

Simple Summary The immune system spontaneously recognizes and destroys foreign cells
and organs when grafted into a genetically different individual. Organ transplantation is only …

Meniere Disease (MD) is a chronic inner ear disorder characterized by vertigo attacks,
sensorineural hearing loss, tinnitus, and aural fullness. Extensive evidence supporting the …

Highlights•Autoimmune diseases impact more women than men and are underrepresented
in research.•Imbalance of T-cell populations is inherent to most autoimmune …

Background The emergence of nonresponse or resistance to traditional chemotherapeutic
agents is one of the main challenges of colorectal cancer (CRC) therapies. Thus, novel …

Immune dysregulation has long been proposed to be associated with adenomyosis, but the
underlying mediators and mechanisms remain largely unexplored. Here, we used flow …

CD8+ T lymphocytes are one of the main effector cells of the immune system, they protect
the organism against intracellular threats such as viruses and bacteria, as well as …

Introduction Interferon-gamma (IFN-γ) is pivotal in orchestrating immune responses during
healthy pregnancy. However, its dysregulation, often due to autoimmunity, infections, or …

Exhausted CD8 T cells (TEX) are associated with worse outcome in cancer yet better
outcome in autoimmunity. Building on our past findings of increased TIGIT+ KLRG1+ TEX …

Integrin α4β7+ T cells perpetuate tissue injury in chronic inflammatory diseases, yet their
role in hepatic fibrosis progression remains poorly understood. Here, we report increased …