Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Electrochemical biosensors for whole blood analysis: recent progress, challenges, and future perspectives

S Li, H Zhang, M Zhu, Z Kuang, X Li, F Xu… - Chemical …, 2023 - ACS Publications
Whole blood, as one of the most significant biological fluids, provides critical information for
health management and disease monitoring. Over the past 10 years, advances in …

[HTML][HTML] Metazoan micrornas

DP Bartel - Cell, 2018 - cell.com
MicroRNAs (miRNAs) are∼ 22 nt RNAs that direct posttranscriptional repression of mRNA
targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs …

[HTML][HTML] The role of lncRNA-mediated ceRNA regulatory networks in pancreatic cancer

J Xu, J Xu, X Liu, J Jiang - Cell death discovery, 2022 - nature.com
Abstract Non-coding RNAs (ncRNAs), which occupy the vast majority of human transcripts
are known for their inability to encode proteins. NcRNAs consist of a diverse range of RNA …

Post-transcriptional control of miRNA biogenesis

G Michlewski, JF Cáceres - Rna, 2019 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are important regulators of gene expression that bind complementary
target mRNAs and repress their expression. Precursor miRNA molecules undergo nuclear …

[HTML][HTML] Hypoxic BMSC-derived exosomal miRNAs promote metastasis of lung cancer cells via STAT3-induced EMT

X Zhang, B Sai, F Wang, L Wang, Y Wang, L Zheng… - Molecular cancer, 2019 - Springer
Background Metastasis is the main cause of lung cancer mortality. Bone marrow-derived
mesenchymal stem cells (BMSCs) are a component of the cancer microenvironment and …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

[HTML][HTML] Recent advances in drug delivery systems for targeting cancer stem cells

H Duan, Y Liu, Z Gao, W Huang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Cancer stem cells (CSCs) are a subpopulation of cancer cells with functions similar to those
of normal stem cells. Although few in number, they are capable of self-renewal, unlimited …

An integrated expression atlas of miRNAs and their promoters in human and mouse

D De Rie, I Abugessaisa, T Alam, E Arner, P Arner… - Nature …, 2017 - nature.com
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As
part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) …

Non-coding RNAs: classification, biology and functioning

S Hombach, M Kretz - Non-coding RNAs in colorectal cancer, 2016 - Springer
One of the long-standing principles of molecular biology is that DNA acts as a template for
transcription of messenger RNAs, which serve as blueprints for protein translation. A rapidly …