The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …

Dense packaging of genomic DNA is crucial for organismal survival, as DNA length always
far exceeds the dimensions of the cells that contain it. Organisms, therefore, use …

Transcription generates local topological and mechanical constraints on the DNA fiber,
leading to the generation of supercoiled chromosome domains in bacteria. However, the …

Structural maintenance of chromosome (SMC) complexes fold DNA by loop extrusion to
support chromosome segregation and genome maintenance. Wadjet systems …

All cells fold their genomes, including bacterial cells, where the chromosome is compacted
into a domain-organized meshwork called the nucleoid. How compaction and domain …

Bacterial topoisomerase I (TopoI) removes excessive negative supercoiling and is thought to
relax DNA molecules during transcription, replication and other processes. Using ChIP-Seq …

Bio-fortification is a new, viable, cost-effective, and long-term method of administering crucial
minerals to a populace with limited exposure to diversified foods and other nutritional …

In all living cells, genomic DNA is compacted through interactions with dedicated proteins
and/or the formation of plectonemic coils. In bacteria, DNA compaction is achieved …

When replication forks encounter template lesions, one result is lesion skipping, where the
stalled DNA polymerase transiently stalls, disengages, and then reinitiates downstream to …

Streptococcus iniae is a re-emerging bacterial pathogen in freshwater and marine
aquaculture worldwide. There are no commercial vaccines available for S. iniae in the …