Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …

Metformin is considered the first-choice drug for type 2 diabetes treatment. Actually,
pleiotropic effects of metformin have been recognized, and there is evidence that this drug …

DNA methylation is crucial for chromatin structure and gene expression and its aberrancies,
including the global “hypomethylator phenotype”, are associated with cancer. Here we show …

Cancer cells depend on metabolic reprogramming for survival, undergoing profound shifts in
nutrient sensing, nutrient uptake and flux through anabolic pathways, in order to drive …

Molecular genetic approaches are now mandatory for cancer diagnostics, especially for
brain tumors. Genotype‐based diagnosis has predominated over the phenotype‐based …

Over the past few decades, many researchers have individually identified tumor-related
genes, and have accumulated information on their basic research in a database. With the …

Accumulated alterations in metabolic control provide energy and anabolic demands for
enhanced cancer cell proliferation. Exemplified by the Warburg effect, changes in glucose …

Background and aims Metabolic reprogramming has been found to be a typical feature of
tumors. Hepatocellular carcinoma (HCC), a cancer with high morbidity and mortality, has …

Keeping chromatin in a stable state is essential for genome stability, scheduled transcription,
replication, DNA repair, and precise and reliable chromosome segregation and telomere …