Curing cancer through precision medicine is the paramount aim of the new wave of
molecular and genomic therapies. Currently, whether patients with non-reproductive …

X inactivation represents a complex multi-layer epigenetic mechanism that profoundly
modifies chromatin composition and structure of one X chromosome in females. The …

Understanding sex differences in physiology and disease requires the identification of the
molecular agents that cause phenotypic sex differences. Two groups of such agents are …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of
unexplained intellectual disability (ID) cases in females and are associated with autism …

X inactivation (XCI) is triggered by upregulation of XIST, which coats the chromosome in cis,
promoting formation of a heterochromatic domain (Xi). XIST role beyond initiation of XCI is …

Sex chromosomes originate as a pair of homologus autosomes that then follow a general
pattern of divergence. This is evident in mammalian sex chromosomes, which have …

For many decades to date, neuroendocrinologists have delved into the key contribution of
gonadal hormones to the generation of sex differences in the developing brain and the …

Background Stroke is a sexually dimorphic disease. Previous studies have found that young
females are protected against ischemia compared to males, partially due to the protective …

The X Chromosome plays an important role in human development and disease. However,
functional genomic and disease association studies of X genes greatly lag behind …

One of the two X chromosomes in females is epigenetically inactivated, thereby
compensating for the dosage difference in X‐linked genes between XX females and XY …