Learning Objectives After completing this course, the reader will be able to: Describe the
role played by EGF and EGFR in lung carcinogenesis. Discuss how different polymorphic …

Developmental process to gastric cancer by Helicobacter pylori infection consists of three
steps:(1) H. pylori infection;(2) gastric atrophy development; and (3) carcinogenesis. In each …

The prognostic significance of inherited genetic variants in advanced-stage non-small cell
lung cancer (NSCLC) patients remains unknown. In this study, we genotyped 271 817 single …

Purpose: The epidermal growth factor (EGF) pathway is important in esophageal
adenocarcinoma (EAC) tumorigenesis. We hypothesized that the EGF A61G homozygous …

Recent years have seen a considerable emphasis on growth factors and the elucidation of
their mode of function, which has led to the recognition that growth factors, their receptors as …

Background: Cetuximab has shown significant clinical activity in metastatic colon cancer.
However, cetuximab-containing neoadjuvant chemoradiation has not been shown to …

Apart from Helicobacter pylori infection and lifestyle factors, host genetic susceptibility has
been suggested to contribute to individual variation in gastric cancer risk as well. Aiming to …

Objective:: Epidermal growth factor (EGF) has many biological functions, including
mitogenesis, tumorigenesis, and proliferation of epidermal tissues. Previous studies have …

Background: Numerous studies have investigated the risk of cancer associated with the
polymorphism of epidermal growth factor (EGF) 61A> G, but the results have been …

EGF promoter polymorphisms are observed to modulate EGF levels and thought to have
effect on susceptibility to various carcinomas but the results are inconsistent. In this meta …