Emerging era of “somes”: Polymersomes as versatile drug delivery carrier for cancer diagnostics and therapy
Over the past two decades, polymersomes have been widely investigated for the delivery of
diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric …
diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric …
Reduction-sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy
The development of smart delivery systems that are robust in circulation and quickly release
drugs following selective internalization into target cancer cells is a key to precision cancer …
drugs following selective internalization into target cancer cells is a key to precision cancer …
Stimuli-responsive polymersomes for biomedical applications
Polymersomes, the structural analogues of liposomes, are hollow structures enclosed by a
bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed …
bilayer membrane made from amphiphilic copolymers. Polymersomes have been proposed …
Nano codelivery of oxaliplatin and folinic acid achieves synergistic chemo-immunotherapy with 5-fluorouracil for colorectal cancer and liver metastasis
FOLFOX, the combinational strategy of folinic acid (FnA), 5-fluorouracil (5-Fu), and
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
oxaliplatin (OxP), has been used as standard treatment of colorectal cancer (CRC) for …
In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy
A cancer vaccine is an important form of immunotherapy. Given their effectiveness for
antigen processing and presentation, dendritic cells (DCs) have been exploited in the …
antigen processing and presentation, dendritic cells (DCs) have been exploited in the …
Apolipoprotein E peptide-directed chimeric polymersomes mediate an ultrahigh-efficiency targeted protein therapy for glioblastoma
The inability to cross the blood–brain barrier (BBB) prevents nearly all chemotherapeutics
and biotherapeutics from the effective treatment of brain tumors, rendering few …
and biotherapeutics from the effective treatment of brain tumors, rendering few …
1, 2-Dithiolane-derived dynamic, covalent materials: cooperative self-assembly and reversible cross-linking
X Zhang, RM Waymouth - Journal of the American Chemical …, 2017 - ACS Publications
The use of dithiolane-containing polymers to construct responsive and dynamic networks is
an attractive strategy in material design. Here, we provide a detailed mechanistic study on …
an attractive strategy in material design. Here, we provide a detailed mechanistic study on …
Size-transformable antigen-presenting cell–mimicking nanovesicles potentiate effective cancer immunotherapy
Artificial antigen-presenting cells (aAPCs) can stimulate CD8+ T cell activation. While
nanosized aAPCs (naAPCs) have a better safety profile than microsized (maAPCs), they …
nanosized aAPCs (naAPCs) have a better safety profile than microsized (maAPCs), they …
Protein toxin chaperoned by LRP‐1‐targeted virus‐mimicking vesicles induces high‐efficiency glioblastoma therapy in vivo
Glioblastoma is a most intractable and high‐mortality malignancy because of its extremely
low drug accessibility resulting from the blood–brain barrier (BBB). Here, it is reported that …
low drug accessibility resulting from the blood–brain barrier (BBB). Here, it is reported that …
Virus‐mimicking chimaeric polymersomes boost targeted cancer siRNA therapy in vivo
Small interfering RNA (siRNA) offers a highly selective and effective pharmaceutical for
various life‐threatening diseases, including cancers. The clinical translation of siRNA is …
various life‐threatening diseases, including cancers. The clinical translation of siRNA is …