Immunotherapy is regarded as the most promising treatment for cancers. Various cancer
immunotherapies, including adoptive cellular immunotherapy, tumor vaccines, antibodies …

Monocytes are innate blood cells that maintain vascular homeostasis and are early
responders to pathogens in acute infections. There are three well-characterized classes of …

From a technical point of view a flow cytometer is a light detection device capable of
detecting photons of different wavelengths over a high dynamic range. In order to achieve a …

The liver is a central immunological organ with a high exposure to circulating antigens and
endotoxins from the gut microbiota, particularly enriched for innate immune cells …

Human monocytes have been grouped into classical (CD14++ CD16−), non-classical
(CD14dimCD16++), and intermediate (CD14++ CD16+) subsets. Documentation of normal …

Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …

Macrophages are abundant in almost all tissues of all multicellular organisms, estimated to
total 10 10 cells in adult humans. Macrophage function is essential for health, as strikingly …

The purpose of this perspective is to describe a critical advance in understanding how
immune responses work. Macrophages are required for all animal life:'Inhibit'type …

Nonclassical patrolling monocytes are characterized by their unique ability to actively patrol
the vascular endothelium under homeostatic and inflammatory conditions. Patrolling …

Tumor-associated macrophages (TAM) form a major component of the tumor stroma.
However, important concepts such as TAM heterogeneity and the nature of the monocytic …