Multiple drug resistance (MDR), referring to the resistance of cancer cells to a broad
spectrum of structurally and mechanistically unrelated drugs across membranes, severely …

Resistance to conventional and target specific antitumor drugs still remains one of the major
cause of treatment failure and patience death. This condition often involves ATP-binding …

Drug resistance remains the major cause of cancer treatment failure especially at the late
stage of the disease. However, based on their versatile chemistry, metal and metalloid …

Most of oral targeted therapies are tyrosine kinase inhibitors (TKIs). Oral administration
generates a complex step in the pharmacokinetics (PK) of these drugs. Inter-individual PK …

The extrusion of anticancer drugs by members of the ATP-binding cassette (ABC)
transporter family is one of the most widely recognized mechanisms of multidrug resistance …

Background Human epidermal growth factor receptor-2 (HER2)-targeted therapies prolong
survival in HER2-positive breast cancer patients. Benefit stems primarily from improved …

Adenine triphosphate (ATP)-binding cassette (ABC) transporter proteins, such as ABCB1/P-
glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP), transport various …

Although BRAF and MEK inhibitors have proven clinical benefits in melanoma, most patients
develop resistance. We report a de novo MEK2-Q60P mutation and BRAF gain in a …

In addition to each of the factors that govern the identification of a successful oncology drug
candidate, drug discovery aimed at treating neurological cancer must also consider the …

The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar
endo‐and xenobiotics in the human body, especially in the tissue barriers and the …