Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.
Although these structures were first described more than a century ago, the full scope of their …

The utility of point-of-care ultrasound is well supported by the medical literature.
Consequently, pediatric emergency medicine providers have embraced this technology in …

Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …

To prevent dehydration, terrestrial animals and humans have developed a sensitive and
versatile system to maintain their water homeostasis. In states of hypernatremia or …

TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes …

Hepatorenal fibrocystic diseases (HRFCDs) are among the most common inherited human
disorders. The discovery that proteins defective in the autosomal dominant and recessive …

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by
mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is …

Objective. To present any congenital anomalies with respect to tumor necrosis factor (TNF)
antagonists reported to the US Food and Drug Administration (FDA) to determine if there are …

How extracellular cues are transduced to the nucleus is a fundamental issue in biology. The
paralogous WW-domain proteins YAP (Yes-associated protein) and TAZ (transcriptional …

Cystic renal lesions are commonly encountered in abdominal imaging. Although most cystic
renal lesions are benign simple cysts, complex renal cysts, infectious cystic renal disease …