The primary cilium as the cell's antenna: signaling at a sensory organelle
V Singla, JF Reiter - science, 2006 - science.org
Almost every vertebrate cell has a specialized cell surface projection called a primary cilium.
Although these structures were first described more than a century ago, the full scope of their …
Although these structures were first described more than a century ago, the full scope of their …
[HTML][HTML] Pediatric emergency medicine point-of-care ultrasound: summary of the evidence
JR Marin, AM Abo, AC Arroyo, SJ Doniger… - Critical ultrasound …, 2016 - Springer
The utility of point-of-care ultrasound is well supported by the medical literature.
Consequently, pediatric emergency medicine providers have embraced this technology in …
Consequently, pediatric emergency medicine providers have embraced this technology in …
[HTML][HTML] Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy
NA Zaghloul, N Katsanis - The Journal of clinical …, 2009 - Am Soc Clin Investig
Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …
progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have …
[HTML][HTML] Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption
M Boone, PMT Deen - Pflügers Archiv-European Journal of Physiology, 2008 - Springer
To prevent dehydration, terrestrial animals and humans have developed a sensitive and
versatile system to maintain their water homeostasis. In states of hypernatremia or …
versatile system to maintain their water homeostasis. In states of hypernatremia or …
Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ
R Makita, Y Uchijima, K Nishiyama… - American Journal …, 2008 - journals.physiology.org
TAZ (transcriptional coactivator with PDZ-binding motif), also called WWTR1 (WW domain
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes …
containing transcription regulator 1), is a 14-3-3-binding molecule homologous to Yes …
Liver and kidney disease in ciliopathies
M Gunay‐Aygun - American Journal of Medical Genetics Part C …, 2009 - Wiley Online Library
Hepatorenal fibrocystic diseases (HRFCDs) are among the most common inherited human
disorders. The discovery that proteins defective in the autosomal dominant and recessive …
disorders. The discovery that proteins defective in the autosomal dominant and recessive …
A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by
mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is …
mutations in PKD1 or PKD2 and affects one in 500–1000 humans. Limited treatment is …
A safety assessment of tumor necrosis factor antagonists during pregnancy: a review of the Food and Drug Administration database
JD Carter, A Ladhani, LR Ricca, J Valeriano… - The Journal of …, 2009 - jrheum.org
Objective. To present any congenital anomalies with respect to tumor necrosis factor (TNF)
antagonists reported to the US Food and Drug Administration (FDA) to determine if there are …
antagonists reported to the US Food and Drug Administration (FDA) to determine if there are …
YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human disease
How extracellular cues are transduced to the nucleus is a fundamental issue in biology. The
paralogous WW-domain proteins YAP (Yes-associated protein) and TAZ (transcriptional …
paralogous WW-domain proteins YAP (Yes-associated protein) and TAZ (transcriptional …
CT and MR imaging for evaluation of cystic renal lesions and diseases
CG Wood III, LRJ Stromberg III, CB Harmath… - Radiographics, 2015 - pubs.rsna.org
Cystic renal lesions are commonly encountered in abdominal imaging. Although most cystic
renal lesions are benign simple cysts, complex renal cysts, infectious cystic renal disease …
renal lesions are benign simple cysts, complex renal cysts, infectious cystic renal disease …