Transplanting marginal organs in the era of modern machine perfusion and advanced organ monitoring

T Resch, B Cardini, R Oberhuber… - Frontiers in …, 2020 - frontiersin.org
Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

The next frontier of regulatory T cells: Promising immunotherapy for autoimmune diseases and organ transplantations

LV Terry, YH Oo - Frontiers in immunology, 2020 - frontiersin.org
Regulatory T cells (Tregs) are crucial in maintaining tolerance. Hence, Treg immunotherapy
is an attractive therapeutic option in autoimmune diseases and organ transplantations …

Organ restoration with normothermic machine perfusion and immune reaction

A Parente, DC Osei-Bordom, V Ronca… - Frontiers in …, 2020 - frontiersin.org
Liver transplantation is the only recognized effective treatment for end-stage liver disease.
However, organ shortages have become the main challenge for patients and physicians …

The effect of preservation temperature on liver, kidney, and pancreas tissue ATP in animal and preclinical human models

MI Bellini, J Yiu, M Nozdrin, V Papalois - Journal of Clinical Medicine, 2019 - mdpi.com
The recent advances in machine perfusion (MP) technology involve settings ranging
between hypothermic, subnormothermic, and normothermic temperatures. Tissue level …

Assessment of organ quality in kidney transplantation by molecular analysis and why it may not have been achieved, yet

S Von Moos, E Akalin, V Mas, TF Mueller - Frontiers in immunology, 2020 - frontiersin.org
Donor organ shortage, growing waiting lists and substantial organ discard rates are key
problems in transplantation. The critical importance of organ quality in determining long-term …

Machine Perfusion and Bioengineering Strategies in Transplantation—Beyond the Emerging Concepts

A Niroomand, GE Nita… - Transplant International, 2024 - frontierspartnerships.org
Solid organ transplantation has progressed rapidly over the decades from the first
experimental procedures to its role in the modern era as an established treatment for end …

Working towards an ERAS protocol for pancreatic transplantation: a narrative review

M Elango, V Papalois - Journal of Clinical Medicine, 2021 - mdpi.com
Enhanced recovery after surgery (ERAS) initially started in the early 2000s as a series of
protocols to improve the perioperative care of surgical patients. They aimed to increase …

Development and validation of a quantitative electron microscopy score to assess acute cellular stress in the human exocrine pancreas

N Kattner, N Dyson, Y Bury, D Tiniakos… - The Journal of …, 2021 - Wiley Online Library
The pancreas is particularly sensitive to acute cellular stress, but this has been difficult to
evaluate using light microscopy. Pancreatic ischaemia associated with deceased organ …

[HTML][HTML] Back-table surgery pancreas allograft for transplantation: implications in complications

J Briceño, JM Sánchez-Hidalgo… - World journal of …, 2021 - ncbi.nlm.nih.gov
To describe the main aspects of back-table surgery in pancreatic graft and the problems
arising from poor technique. Back-table surgery for pancreatic graft is a complex, meticulous …

Breaking the limits of experimental pancreas transplantation: Working toward the clinical ideal graft

J Ferrer-Fàbrega, E Folch-Puy… - Frontiers in …, 2022 - frontiersin.org
Pancreas transplantation is, at present, the only curative treatment for type-1 diabetes that
maintains normoglycemia thus avoiding complications arising from poor glycemic control …