The selection of the right antibiotic and right dose necessitates clinicians understand the
contribution of pharmacokinetic variability stemming from age‐related physiologic …

To date, up to 65% of drugs used in neonates and infants are off-label or unlicensed, as they
were implemented in clinical care without the usual regulatory phases of pharmacological …

Vancomycin is a fundamental antibiotic in the management of severe Gram‐positive
infections. Inappropriate vancomycin dosing is associated with therapeutic failure, bacterial …

Objectives To develop a population pharmacokinetic (PK) model for vancomycin in Chinese
neonates and infants less than 2 months of age (young infants) with a wide gestational age …

Introduction: For safe and effective use of antibacterial agents in neonates, specific
knowledge on the pharmacokinetics (PK) and its covariates is needed. This necessitates a …

Optimal dosing of gentamicin in neonates is still a matter of debate despite its common use.
We identified gentamicin dosing regimens from eight international guidelines and seven …

Sepsis in neonates and infants remains a major cause of death despite a decline in child
mortality and morbidity over the last decades. A key factor in further reducing poor clinical …

The selection of an appropriate dose of a given antibiotic for a neonate not only requires
knowledge of the drug's basic pharmacokinetic (PK) and pharmacodynamic (PD) properties …

Background Despite the widespread use of amoxicillin in young children, efforts to establish
the feasibility of simplified dosing regimens in resource-limited settings have relied upon …

Rational drug use in special populations is a clinical problem that doctors and pharma-cists
must consider seriously. Neonates are the most physiologically immature and vulnerable to …