Abstract Short Linear Motifs (SLiMs) are the smallest structural and functional components of
modular eukaryotic proteins. They are also the most abundant, especially when considering …

Targeted protein degradation (TPD) by PROTAC (proteolysis-targeting chimera) and
molecular glue small molecules is an emerging therapeutic strategy. To expand the roster of …

Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular
proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly …

Protein ubiquitylation typically involves isopeptide bond formation between the C-terminus
of ubiquitin to the side-chain amino group on Lys residues. However, several ubiquitin …

The transporter associated with antigen processing (TAP) is a key player in the major
histocompatibility class I-restricted antigen presentation and an attractive target for immune …

Chemically induced protein degradation is a powerful strategy for perturbing cellular
biochemistry. The predominant mechanism of action for protein degrader drugs involves an …

In ribosome-associated quality control (RQC), nascent polypeptides produced by interrupted
translation are modified with C-terminal polyalanine tails (" Ala-tails") that function outside …

E3 ubiquitin ligases determine the specificity of eukaryotic protein degradation by selective
binding to destabilizing protein motifs, termed degrons, in substrates for ubiquitin-mediated …

The cullin–RING ubiquitin ligase (CRL) network comprises over 300 unique complexes that
switch from inactive to activated conformations upon site-specific cullin modification by the …

Protein ubiquitination is a post-translational modification that entails the covalent attachment
of the small protein ubiquitin (Ub), which acts as a signal to direct protein stability …