Most individuals adjust their caffeine intake according to the objective and subjective effects
induced by the methylxanthine. However, to reach the desired effects, the quantity of …

Caffeine is consumed by over 80% of US adults. This review examines the effects caffeine
has on cognitive and physical function, since most real-world activities require complex …

Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

Caffeine is the most widely consumed psychoactive drug in the world. Natural sources of
caffeine include coffee, tea, and chocolate. Synthetic caffeine is also added to products to …

To date, one of the most heavily cited assessments of caffeine safety in the peer-reviewed
literature is that issued by Health Canada (Nawrot et al., 2003). Since then,> 10,000 papers …

After more than two decades of preclinical and clinical studies, on August 27, 2019, the US
Food and Drug Administration (FDA) approved the adenosine A 2A receptor antagonist …

Following critical evaluation of the available literature to date, The International Society of
Sports Nutrition (ISSN) position regarding caffeine intake is as follows: Supplementation with …

Caffeine is a widely recognized psychostimulant compound with a long history of
consumption by humans. While it has received a significant amount of attention there is still …

Adenosine signalling has long been a target for drug development, with adenosine itself or
its derivatives being used clinically since the 1940s. In addition, methylxanthines such as …

Background Caffeine is a widely used ergogenic aid with most research suggesting it
confers the greatest effects during endurance activities. Despite the growing body of …