The discovery of innovative small-molecule drugs is a challenging endeavor. Medicinal
chemists need to continuously optimize the properties of bioactive compounds while at the …

We report the synthesis of a new palladium complex (1a) bearing two different P-donors, di
(1-adamantyl) phosphinous acid and triphenylphosphine. A heteroleptic complex with a …

Tyrosine kinases (TKs) are emerging as important targets in cancer therapy and some of
their inhibitors, TKIs (eg imatinib and nilotinib), are FDA-approved drugs that are used as …

Systematically studying the lipophilicity of phosphorus compounds is of great importance for
many chemical and biological fields and particularly for medicinal chemistry. Here, we report …

We report a simple photocatalytic protocol for the direct synthesis of γ-amino phosphonates
via the α-C–H alkylation of unprotected, aliphatic primary amines with diethyl …

Catalytic systems that are readily modifiable to achieve olefin migration or remote
functionalization are highly sought after in chemical synthesis. Here, we show that the …

In this study, we present an N-heterocyclic carbene-catalyzed method for the radical
acylphosphorylation of alkenes. Electrochemical investigations were employed to identify an …

A highly stereo-and chemoselective intermolecular coupling of diverse heterocycles with
dialkynylphosphine oxides has been realized via cobalt/rhodium-catalyzed C–H bond …

This study reports the first general, practical, and facile synthesis of phosphorus-substituted
1, 3, 4-thiadiazolines starting from phosphorylthioformic acid hydrazides and ketones …

We report the discovery of a straightforward protocol to convert phenols into the
corresponding aryl triflates using 1‐methyl‐3‐((trifluoromethyl) sulfonyl)‐1, 3‐dihydro‐2H …