Interleukins in cancer: from biology to therapy
Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …
Cytokine networks in the pathogenesis of rheumatoid arthritis
N Kondo, T Kuroda, D Kobayashi - International journal of molecular …, 2021 - mdpi.com
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …
inflammation causing progressive joint damage that can lead to lifelong disability. The …
Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
Role of the IL-23/IL-17 pathway in rheumatic diseases: an overview
C Schinocca, C Rizzo, S Fasano, G Grasso… - Frontiers in …, 2021 - frontiersin.org
Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …
The function and role of the Th17/Treg cell balance in inflammatory bowel disease
J Yan, M Luo, Z Chen, B He - Journal of immunology research, 2020 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder. The
pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T …
pathogenesis of IBD is not yet clear. Studies have shown that the imbalance between T …
Immunomodulatory activities of polysaccharides from Ganoderma on immune effector cells
L Ren, J Zhang, T Zhang - Food Chemistry, 2021 - Elsevier
Polysaccharides are the most abundant bioactive compounds in Ganoderma and have been
widely used as dietary supplements in traditional Chinese medicine for thousands of years …
widely used as dietary supplements in traditional Chinese medicine for thousands of years …
Mechanisms of disease: inflammatory bowel diseases
GP Ramos, KA Papadakis - Mayo Clinic Proceedings, 2019 - Elsevier
Inflammatory bowel diseases (IBDs), represented by Crohn disease and ulcerative colitis,
are associated with major morbidity in Western countries and with increasing incidence in …
are associated with major morbidity in Western countries and with increasing incidence in …
Crosstalk of inflammatory cytokines within the breast tumor microenvironment
O Habanjar, R Bingula, C Decombat… - International journal of …, 2023 - mdpi.com
Several immune and immunocompetent cells, including dendritic cells, macrophages,
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the …
Neuroinflammation in Alzheimer's disease
IG Onyango, GV Jauregui, M Čarná, JP Bennett Jr… - Biomedicines, 2021 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …
Strategies to therapeutically modulate cytokine action
WJ Leonard, JX Lin - Nature Reviews Drug Discovery, 2023 - nature.com
Cytokines are secreted or membrane-presented molecules that mediate broad cellular
functions, including development, differentiation, growth and survival. Accordingly, the …
functions, including development, differentiation, growth and survival. Accordingly, the …