Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Many circulating proteins are associated with the presence or severity of disease. However,
whether these protein biomarkers are causal for disease development is usually unknown …

Over the last 2 decades, novel therapies targeting several immune pathways have been
developed for the treatment of patients with inflammatory bowel disease (IBD). Although anti …

Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses.
Macrophages are roughly categorized into two different subsets named inflammatory M1 …

CD4+ T helper (Th) cells are critical in homeostasis and host defense but are also central to
the development of various autoimmune diseases if they become dysregulated. Specifically …

Here we perform phage-assisted continuous evolution (PACE) of TEV protease, which
canonically cleaves ENLYFQS, to cleave a very different target sequence, HPLVGHM, that is …

Psoriasis is a multifactorial recalcitrant inflammatory skin disease characterized by
bothersome scaly reddish plaques especially on frequently chafed body parts, such as the …

Th17 cells, known as a highly pro-inflammatory subtype of Th cells, are involved very early
in numerous aspects of multiple sclerosis (MS) and experimental autoimmune …

Genome-wide association studies (GWAS) aim to identify genetic factors associated with
phenotypes. Standard analyses test variants for associations individually. However, variant …

Objective Evaluation of the efficacy and safety of guselkumab, a human monoclonal
antibody targeting the interleukin-23p19 subunit, in patients with psoriatic arthritis (PsA) …