[HTML][HTML] Non-coding RNAs in regulating plaque progression and remodeling of extracellular matrix in atherosclerosis

D Singh, V Rai, DK Agrawal - International Journal of Molecular Sciences, 2022 - mdpi.com
Non-coding RNAs (ncRNAs) regulate cell proliferation, migration, differentiation,
inflammation, metabolism of clinically important biomolecules, and other cellular processes …

Targeting PPARs for therapy of atherosclerosis: A review

M Miao, X Wang, T Liu, YJ Li, WQ Yu, TM Yang… - International journal of …, 2023 - Elsevier
Atherosclerosis, a chief pathogenic factor of cardiovascular disease, is associated with many
factors including inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator …

[HTML][HTML] Butyrate suppresses atherosclerotic inflammation by regulating macrophages and polarization via GPR43/HDAC-miRNAs axis in ApoE−/− mice

H Ma, L Yang, Y Liu, R Yan, R Wang, P Zhang, Z Bai… - PLoS …, 2023 - journals.plos.org
Chronic low-grade inflammation is regarded to an important signature of atherosclerosis
(AS). Macrophage (Mψ) and related polarization have been demonstrated to play a crucial …

Targeted intervention of natural medicinal active ingredients and traditional Chinese medicine on epigenetic modification: possible strategies for prevention and …

W Wang, H Li, Y Shi, J Zhou, GJ Khan, J Zhu, F Liu… - Phytomedicine, 2024 - Elsevier
Background Atherosclerosis is a deadly consequence of cardiovascular disease and has
very high mortality rate worldwide. The epigenetic modifications can regulate the …

[HTML][HTML] Exosomes in cardiovascular disease: from mechanism to therapeutic target

AB Reiss, S Ahmed, M Johnson, U Saeedullah… - Metabolites, 2023 - mdpi.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally. In
recent decades, clinical research has made significant advances, resulting in improved …

Epigenetic regulation of inflammation: The metabolomics connection

S Rath, YM Hawsawi, F Alzahrani, MI Khan - Seminars in Cell & …, 2022 - Elsevier
Epigenetic factors are considered the regulator of complex machinery behind inflammatory
disorders and significantly contributed to the expression of inflammation-associated genes …

[HTML][HTML] PPARγ Gene polymorphisms, metabolic disorders, and coronary artery disease

Y Song, S Li, C He - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Being activated by endogenous and exogenous ligands, nuclear receptor peroxisome
proliferator-activated receptor gamma (PPARγ) enhances insulin sensitivity, promotes …

Two sides of the same coin: Non-alcoholic fatty liver disease and atherosclerosis

B Zhu, H Wu, KS Li, S Eisa-Beygi, B Singh… - Vascular …, 2023 - Elsevier
The prevalence of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis remain
high, which is primarily due to widespread adoption of a western diet and sedentary lifestyle …

CircIRAK1 aggravates ox-LDL-induced endothelial cell injury in atherosclerosis via TRIM14 upregulation by binding to miR-330-5p 1

F Liu, B Gao, Y Wang - Clinical Hemorheology and …, 2022 - content.iospress.com
BACKGROUND: Atherosclerosis (AS) is a common inflammatory cardiovascular disease,
and circular RNAs (circRNAs) are associated with the pathogenesis of AS. CircRNA …

[HTML][HTML] Epigenetic modifications as therapeutic targets in atherosclerosis: a focus on DNA methylation and non-coding RNAs

H Sum, AC Brewer - Frontiers in Cardiovascular Medicine, 2023 - frontiersin.org
Significant progress in the diagnosis and treatment of cardiovascular disease (CVD) has
been made in the past decade, yet it remains a leading cause of morbidity and mortality …