The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Background Quercetin, a bioflavonoid abundant in grapefruit, onion, berries, etc., has vast
therapeutic potential, especially against Type 2 diabetes and its complications. Quercetin …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.
Treatment of type 2 diabetes has been limited by little translational knowledge of insulin …

Low-volume high-intensity interval training (HIT) is emerging as a time-efficient exercise
strategy for improving health and fitness. This form of exercise has not been tested in type 2 …

Objective We compared the effects of high-intensity interval training (HIIT) and moderate-
intensity continuous training (MICT) on insulin sensitivity and other important metabolic …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

The benefits of endurance exercise on general health make it desirable to identify orally
active agents that would mimic or potentiate the effects of exercise to treat metabolic …