Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Multiple epidemiological studies have documented an association between metformin, used
for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line …

In recent years, several studies have presented evidence suggesting a potential role for
metformin in anti-cancer therapy. Preclinical studies have demonstrated several anticancer …

Purpose: The tumor immune microenvironment (TIME) has an important impact on response
to cancer immunotherapy using immune checkpoint inhibitors. Specifically, an “infiltrated …

The precise role of 5′ AMP-activated kinase (AMPK) in cancer and its potential as a
therapeutic target is controversial. Although it is well established that activation of this …

Late-phase clinical trials investigating metformin as a cancer therapy are underway.
However, there remains controversy as to the mode of action of metformin in tumors at …

Endometrial cancer (EC) in young women of reproductive age is a relatively rare diagnosis.
However, since in the modern era women delay their childbearing for a variety of social …

Background Endometrial cancer is one of the most common gynecological cancers, which is
frequently preceded by atypical endometrial hyperplasia, a premalignant lesion. Metformin …

Increasing costs, much time consumption and high risk of failure associated with the process
of de novo development of new anticancer drugs have prompted the pharmaceutical …