The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER),
due to genetic determinants and extrinsic environmental factors, leads to endoplasmic …

Cancer poses a substantial risk to human life and wellbeing as a result of its elevated
incidence and fatality rates. Endoplasmic reticulum stress (ERS) is an important pathway …

Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in
adolescents. With the application of new chemotherapy regimens, finding new and effective …

Glutamine (Gln) is a critical nutrient required by neonatal mammals for intestinal growth,
especially for newborn piglets. However, the mechanisms underlying the role of Gln in …

Abstract Tris (1, 3-dichloro-2-propyl) phosphate (TDCIPP) is a frequently detected
organophosphorus flame retardants (OPFRs) in various environmental media, and has been …

Chinese herbs have been used to treat small-cell lung cancer (SCLC) due to their low
toxicity and significant efficacy. This study focused on oridonin, a natural compound …

Background: Diabetic cardiomyopathy (DCM) is one of the serious microvascular
complications of diabetes mellitus. It is often associated with clinical manifestations such as …

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting reaction in the
de novo synthesis pathway of guanine nucleotides that is highly required for cancer cell …

Colorectal cancer (CRC) is a significant global health burden, with high morbidity and
mortality rates. It is often diagnosed at middle to advanced stage, affecting approximately …

Endoplasmic reticulum (ER) homeostasis is essential for maintaining human health, and
once imbalanced, it will trigger endoplasmic reticulum stress (ERS), which participates in the …